Rabbit Secondary Antibodies
Cayman Chemical Grnzyme BCTerm RabbIt Mo 100uL
An androgenically inactive metabolite of testosterone and androstenedione potentiates GABA-induced chloride currents in HEK293 cells expressing rat a1B2Y2L subunit-containing GABAA receptors at 10 UM protective against seizures induced by 6 Hz electroshock or PTZ (ED50s 76 9 and 139 mg/kg respectively) increases body temperature in rhesus macaques
ABclonal Technology APC Rabbit anti-Mouse IL-13
Predicted to enable interleukin-13 receptor binding activity Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation Acts upstream of or within cellular response to cytokine stimulus inflammatory response and positive regulation of immune effector process Located in cytoplasm external side of plasma membrane and extracellular space Is expressed in gut liver male reproductive gland or organ and thymus Used to study atopic dermatitis Human ortholog(s) of this gene implicated in several diseases including allergic disease (multiple) autoimmune disease (multiple) diffuse scleroderma lung disease (multiple) and nose disease (multiple) Orthologous to human IL13 (interleukin 13)
Cayman Chemical CD1n-Term RabbIt Monclon 100uL
A CaMKK inhibitor (IC50s 120 and 40 ng/ml for CaMKKa and CaMKKB respectively) selective for CaMKKs over CaMKI CaMKII CaMKIV MLCK PKC PKA and p42 MAPK (IC50s ≥ 10000 ng/ml for all) inhibits phosphorylation of CaMKI and AMPK in chicken sperm in the presence of extracellular calcium as well as reduces chicken sperm motility decreases Npy and Agrp expression and cumulative food intake in mice at 20 M 0.5 L/hour i.c.v. increases cortical striatal and total infarct volume in a mouse model of MCAO-induced focal transient cerebral ischemia at 3 g/animal i.c.v.
Cayman Chemical TNFRSF8CD30C-Term RabbIt 100uL
A BMI1 inhibitor inhibits proliferation of OVCAR-4 and OV-90 cells (IC50s 0 1 UM for both) induces BMI1 degradation in and apoptosis of the same cells reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MDS-L cells at 3 and 0 03 UM respectively reduces tumor growth in a OV-90 orthotopic mouse model of ovarian cancer at 15 mg/kg biweekly
ABclonal Technology RING1B/RNF2 Rabbit mAb
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation The protein encoded by this gene is one of the PcG proteins It has been shown to interact with and suppress the activity of transcription factor CP2 (TFCP2 CP2) Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis as well as in cell proliferation in early development This protein was also found to interact with huntingtin interacting protein 2 (HIP2) an ubiquitin-conjugating enzyme and possess ubiquitin ligase activity
ABclonal Technology NFYA Rabbit mAb
The protein encoded by this gene is one subunit of a trimeric complex forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes Subunit A associates with a tight dimer composed of the B and C subunits resulting in a trimer that binds to DNA with high specificity and affinity The sequence specific interactions of the complex are made by the A subunit suggesting a role as the regulatory subunit In addition there is evidence of post-transcriptional regulation in this gene product either by protein degradation or control of translation Further regulation is represented by alternative splicing in the glutamine-rich activation domain with clear tissue-specific preferences for the two isoforms
ABclonal Technology FGF23 Rabbit mAb
This gene encodes a member of the fibroblast growth factor family of proteins which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes The product of this gene regulates phosphate homeostasis and transport in the kidney The full-length functional protein may be deactivated via cleavage into N-terminal and C-terminal chains Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC)
ABclonal Technology CCL17 Rabbit mAb
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16 Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes The CC cytokines are proteins characterized by two adjacent cysteines The cytokine encoded by this gene displays chemotactic activity for T lymphocytes but not monocytes or granulocytes The product of this gene binds to chemokine receptors CCR4 and CCR8 This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells
Cayman Chemical PLAPNTerm RabbIt Monclon 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
ABclonal Technology Calretinin Rabbit mAb
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily Members of this protein family have six EF-hand domains which bind calcium This protein plays a role in diverse cellular functions including message targeting and intracellular calcium buffering It also functions as a modulator of neuronal excitability and is a diagnostic marker for some human diseases including Hirschsprung disease and some cancers Alternative splicing results in multiple transcript variants
Cayman Chemical LDL RECPTR RabbIt MoncLNa 50uL
A phenolic glucoside with in vitro neuroprotective activity reduces glutamate-induced neurotoxicity by 19.3 in PC12 cells at 10 UM
ABclonal Technology CD307b Rabbit mAb
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology WFS1 Rabbit mAb
This gene encodes a transmembrane protein which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain pancreas heart and insulinoma beta-cell lines Mutations in this gene are associated with Wolfram syndrome also called DIDMOAD (Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness) an autosomal recessive disorder The disease affects the brain and central nervous system Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6) also known as DFNA14 or DFNA38 Alternatively spliced transcript variants have been found for this gene
Cayman Chemical EPCRCD201 RabbIt MoncLNal 50uL
An inhibitor of RNA polymerase I-mediated transcription binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin induces nucleolin mislocalization from the nucleoli to the nucleoplasm in A549 cells at 10 UM induces apoptosis in A549 and HL-60 cells at 5 UM reduces tumor growth in MDA-MB-231 and MiaPaCa-2 mouse xenograft models at 5 mg/kg
ABclonal Technology DDX3X/DDX3Y Rabbit mAb
The protein encoded by this gene is a member of the DEAD-box RNA helicase family defined by the Asp-Glu-Ala-Asp (DEAD) motif with ATP-dependent RNA helicase and RNA-independent ATPase activities Unlike most DEAD-box helicases its ATPase activity is stimulated by both RNA and DNA It plays roles in the nucleus (transcriptional regulation mRNP assembly pre-mRNA splicing and mRNA export) and cytoplasm (translation cellular signaling and viral replication) Misregulation is linked to tumorigenesis This gene has a paralog on the Y chromosome and pseudogenes on chromosomes 4 and X Mutations can cause male infertility reduced germ cell numbers and Sertoli-cell only syndrome Alternative splicing generates multiple isoforms